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Rx One Health (RxOH) is an experiential field-based course that prepares early career professionals and advanced students for immediate engagement in global health careers that demand solid foundations in field and laboratory activities, effective problem-solving skills, and transdisciplinary perspectives. Founded in 2017 and organized by UC Davis, and in collaboration with partners around the world, RxOH has provided One Health competency-based training for over 40 students from four continents.